Kinetic studies of the condensation of aromatic aldehydes with 5-N-benzoylamino-1,3,4-thiadiazole-2-acetonitrile, and their spectrophotometric determination

The condensation reaction of 5-N-benzoylamino-1,3,4-thiadiazole-2-acetonitr ile with aromatic aldehydes in acetonitrile, in the presence of piperidine, has been investigated spectrophotometrically at 50-70 degrees C. The react ion follows second order kinetics overall; first order in each of the react ants, and zero order with respect to piperidine. The rate of condensation i ncreases with the presence of electron-withdrawing groups on the aromatic r ing of the aldehyde. Based on this reaction, the determination of 13 aromat ic aldehydes in a concentration range of 0.106-15.11 mu g/ml is proposed. ( C) 2000 Elsevier Science B.V. All rights reserved.