Functional properties of regenerating skeletal muscle following LIF administration

Authors
Gregorevic, P Hayes, A Lynch, GS Williams, DA
Citation
P. Gregorevic et al., Functional properties of regenerating skeletal muscle following LIF administration, MUSCLE NERV, 23(10), 2000, pp. 1586-1588
Citations number
19
Categorie Soggetti
da verificare
Journal title
MUSCLE & NERVE
ISSN journal
0148639X → ACNP
Volume
23
Issue
10
Year of publication
2000
Pages
1586 - 1588
Database
ISI
SICI code
0148-639X(200010)23:10<1586:FPORSM>2.0.ZU;2-I
Abstract
We tested the hypothesis that periodic systemic administration of the myoge nic cytokine leukemia inhibitory factor (LIF) enhances the functional recov ery of regenerating skeletal muscle following bupivacaine-induced degenerat ion. LIF had no effect on functional capacity or regenerating myofiber size in rat muscles at 7, 14, or 21 days post-injury. The results do not suppor t exogenous administration of LIF as a treatment for acute muscle injury, b ut a more frequent dosing regimen should be tested. (C) 2000 John Wiley & S ons, Inc.