Characterization of a novel ETS gene, TELB, encoding a protein structurally and functionally related to TEL

Authors
Poirel, H Lopez, RG Lacronique, V Della Valle, V Mauchauffe, M Berger, R Ghysdael, J Bernard, OA
Citation
H. Poirel et al., Characterization of a novel ETS gene, TELB, encoding a protein structurally and functionally related to TEL, ONCOGENE, 19(41), 2000, pp. 4802-4806
Citations number
13
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
ONCOGENE
ISSN journal
09509232 → ACNP
Volume
19
Issue
41
Year of publication
2000
Pages
4802 - 4806
Database
ISI
SICI code
0950-9232(20000928)19:41<4802:COANEG>2.0.ZU;2-3
Abstract
The TEL/ETV6 gene is located at 12p13 and is frequently involved in chromos omal translocations in human malignancies usually resulting in the expressi on of fusion proteins between the amino terminal part of TEL, and either un related transcription factors or protein tyrosine kinases. We report here a novel gene named TELB which is located on human chromosomal band 6p21 and encodes a protein highly related to TEL, TELB is widely expressed in differ ent tissues and, similarly to TEL encodes a sequence-specific transcription al repressor.