Chronic fatigue syndrome, fibromyalgia, and multiple chemical sensitivities in a community-based sample of persons with chronic fatigue syndrome-likesymptoms

Objective: The aim of this study was to determine illness comorbidity rates for individuals with chronic fatigue syndrome? (CFS), fibromyalgia (FM), a nd multiple chemical sensitivities (MCS). An additional objective was to id entify characteristics related to the severity of fatigue, disability, and psychiatric comorbidity in each of these illness groups. Methods: A random sample of 18,675 residents in Chicago, Illinois, was first interviewed by t elephone. A control group and a group of individuals with chronic fatigue a ccompanied by at least four minor symptoms associated with CFS received med ical and psychiatric examinations. Results: Of the 32 individuals with CFS, 40.6% met criteria for MCS and 15.6% met criteria for FM. Individuals with MCS or more than one diagnosis reported more physical fatigue than those w ith no diagnosis. Individuals with more than one diagnosis also reported gr eater mental fatigue and were less likely to be working than those with no diagnosis. Individuals with CFS, MCS, FM, or more than one diagnosis report ed greater disability than those with no diagnosis. Conclusions: Rates of c oexisting disorders were lower than those reported in prior studies. Discre pancies may be in part attributable to differences in sampling procedures. People with CFS, MCS, or FM endure significant disability in terms of physi cal, occupational, and social functioning, and those with more than one of these diagnoses also report greater severity of physical and mental fatigue . The findings illustrate differences among the illness groups in the range of functional impairment experienced.