THE EFFECTS OF STERILE OR INFECTED BILE AND DROPPED GALLSTONES IN ABDOMINAL ADHESIONS AND ABSCESS FORMATION

Background: The effects of gallstones and sterile or infected bile on postoperative adhesions and abscess formation were investigated in Spr ague Dawley rats. Methods: The first three groups were injected intrap eritoneally with serum saline, sterile bile, or infected bile, respect ively. Laparotomy was adjusted to the next seven groups. Serum saline, sterile bile, and infected bile were injected in the fourth through s ixth groups intraperitoneally, respectively. Gallstones were placed in traabdominally to the seventh through ninth groups. The injections of sterile bile in group 7 and of infected bile in group 8 were added to laparotomies. Only laparotomy was carried out in group 10. Results: Ab scess formations were seen only in infected-bile-injected groups. Sign ificant adhesion formations were seen in infected-bile groups. Sterile bile and/or gallstones had no significant effect in abscess or adhesi on formation.Conclusions: Results suggest that noninfected gallstones and sterile bile, even in combination, do not increase postoperative i ntraabdominal complications in rats.