Dendritic computation of direction selectivity by retinal ganglion cells

Direction-selective ganglion cells (DSGCs) in the retina respond strongly w hen stimulated by image motion in a preferred direction but are only weakly excited by image motion in the opposite null direction. Such coding repres ents an early manifestation of complex information processing in the visual system, but the cellular locus and the synaptic mechanisms have yet to be elucidated. We recorded the synaptic activity of DSGCs using strategies to observe the asymmetric inhibitory inputs that underlie the generation of di rection selectivity. The critical nonlinear interactions between the excita tory and inhibitory inputs took place postsynaptically within the dendrites of the DSGCs.