I. Villanueva et al., One-step coupling of tris(hydroxymethyl)aminomethane to aliphatic and aromatic carboxylic acids, SYNTHESIS-S, (10), 2000, pp. 1435-1438
A convenient and general method was established to append tri-, hexa-, and
nonadentate ligands about an aromatic or aliphatic core. This approach allo
ws a variety of commercially available carboxylic acids to be transformed t
o their N-tris(hydroxymethyl)methylcarboxamides in one step. The selective
activation of the acid functionality to form the polyhydroxylated dendritic
cores has been achieved using the acyl transfer agent N-ethoxycarbonyl-2-e
thoxy-1,2-dihydroquinoline (EEDQ).