Pseudoaxially disubstituted cyclo-beta(3)-tetrapeptide scaffolds

Authors
Sutton, PW Bradley, A Farras, J Romea, P Urpi, F Vilarrasa, J
Citation
Pw. Sutton et al., Pseudoaxially disubstituted cyclo-beta(3)-tetrapeptide scaffolds, TETRAHEDRON, 56(40), 2000, pp. 7947-7958
Citations number
39
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
56
Issue
40
Year of publication
2000
Pages
7947 - 7958
Database
ISI
SICI code
0040-4020(20000929)56:40<7947:PDCS>2.0.ZU;2-8
Abstract
An N,N-disubstituted cyclo-beta(3)-tetrapeptide, identified as a potential molecular scaffold, has been synthesised on a multigram scale from beta-hom ophenylalanine by employing a nosylate-based protection strategy. C-2-Symme tric derivatives containing pseudoaxial, combinatorially addressable functi onalities have been prepared from the parent cyclopeptide. (C) 2000 Elsevie r Science Ltd. All rights reserved.