Synthesis and Akt inhibitory properties of a 1D-3,4-dideoxyphosphatidylinositol ether lipid

Authors
Hu, YH Meuillet, EJ Qiao, LX Berggren, MM Powis, G Kozikowski, AP
Citation
Yh. Hu et al., Synthesis and Akt inhibitory properties of a 1D-3,4-dideoxyphosphatidylinositol ether lipid, TETRAHEDR L, 41(39), 2000, pp. 7415-7418
Citations number
26
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
39
Year of publication
2000
Pages
7415 - 7418
Database
ISI
SICI code
0040-4039(20000923)41:39<7415:SAAIPO>2.0.ZU;2-R
Abstract
1D-3,4-Dideoxyphosphatidylinositol ether lipid 2, a PI analog, was synthesi zed through a sequence of protection/deprotection protocols and two Barton deoxygenation reactions, starting from L-(-)-quebrachitol. DDPIEL is 18-fol d more potent than its monodeoxy counterpart DPIEL in the inhibition of P13 -K. (C) 2000 Published by Elsevier Science Ltd.