The asymmetric addition of trimethylsilylcyanide to aldehydes catalysed byanionic chiral nucleophiles. Part 2

Authors
Holmes, IP Kagan, HB
Citation
Ip. Holmes et Hb. Kagan, The asymmetric addition of trimethylsilylcyanide to aldehydes catalysed byanionic chiral nucleophiles. Part 2, TETRAHEDR L, 41(39), 2000, pp. 7457-7460
Citations number
16
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
39
Year of publication
2000
Pages
7457 - 7460
Database
ISI
SICI code
0040-4039(20000923)41:39<7457:TAAOTT>2.0.ZU;2-C
Abstract
Studies have been carried out on the addition of trimethylsilylcyanide to a ldehydes using highly active chiral lithium phenolate catalysts. The screen ing of a number of chiral phenolates has resulted in a system which gives t he TMS ethers of cyanohydrins in excellent chemical yields with enantiomeri c excesses of up to 97%. (C) 2000 Elsevier Science Ltd. All rights reserved .