Synthetic study of polyoxypeptin: stereoselective synthesis of the acyl side-chain segment

Authors
Noguchi, Y Yamada, T Uchiro, H Kobayashi, S
Citation
Y. Noguchi et al., Synthetic study of polyoxypeptin: stereoselective synthesis of the acyl side-chain segment, TETRAHEDR L, 41(39), 2000, pp. 7499-7502
Citations number
15
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
39
Year of publication
2000
Pages
7499 - 7502
Database
ISI
SICI code
0040-4039(20000923)41:39<7499:SSOPSS>2.0.ZU;2-6
Abstract
The first synthesis of the acyl side-chain segment of polyoxypeptin, a pote nt inducer of apoptosis in human pancreatic carcinoma AsPC-1, was accomplis hed. The key feature of the present synthesis is the stereospecific palladi um-catalyzed hydrogenolysis of (Z)-alkenyloxirane to anti-hydroxyalkenoate by an improved method. (C) 2000 Elsevier Science Ltd. All rights reserved.