Nucleotide sequence of a new Fc gamma receptor IIIB allele that codes for a neutrophil antigen

Authors
Watanabe, Y Shimada, E Fujiwara, K Nihara, H Shimano, K Mitsunaga, S Tadokoro, K Juji, T
Citation
Y. Watanabe et al., Nucleotide sequence of a new Fc gamma receptor IIIB allele that codes for a neutrophil antigen, TISSUE ANTI, 56(3), 2000, pp. 272-275
Citations number
8
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
TISSUE ANTIGENS
ISSN journal
00012815 → ACNP
Volume
56
Issue
3
Year of publication
2000
Pages
272 - 275
Database
ISI
SICI code
0001-2815(200009)56:3<272:NSOANF>2.0.ZU;2-T
Abstract
A new allele of the human neutrophil antigen (HNA) system (tentatively call ed NA2M) was discovered and its nucleotide sequence was determined. NA2M di ffers in a single nucleotide (193G-->A) from FCGR3B*2(NA2), resulting in an amino acid change (54Glu-->Lys). The frequency of the NA2M gene in the Jap anese population was estimated to be 0.008. Granulocytes of individuals pos sessing NA2M reacted with HNA-1b(NA2)-specific monoclonal antibody (TAG2) i n the GIFT assay.