Docking domains and substrate-specificity determination for MAP kinases

Authors
Sharrocks, AD Yang, SH Galanis, A
Citation
Ad. Sharrocks et al., Docking domains and substrate-specificity determination for MAP kinases, TRENDS BIOC, 25(9), 2000, pp. 448-453
Citations number
35
Categorie Soggetti
Biochemistry & Biophysics
Journal title
TRENDS IN BIOCHEMICAL SCIENCES
ISSN journal
09680004 → ACNP
Volume
25
Issue
9
Year of publication
2000
Pages
448 - 453
Database
ISI
SICI code
0968-0004(200009)25:9<448:DDASDF>2.0.ZU;2-N
Abstract
Signalling specificity in eukaryotic cells is maintained by several mechani sms. One mechanism by which mitogen-activated protein (MAP) kinases ensure their specificity of action is by interacting with their substrates through docking domains. These docking domains recruit the kinases to the correct substrates and enhance their fidelity and efficiency of action. Additional specificity determinants in the substrates serve to enhance the specificity of substrate phosphorylation by MAP kinases further.