DOMAINS WITHIN THE VIBRIO-CHOLERAE TOXIN COREGULATED PILIN SUBUNIT THAT MEDIATE BACTERIAL-COLONIZATION

Citation
Dx. Sun et al., DOMAINS WITHIN THE VIBRIO-CHOLERAE TOXIN COREGULATED PILIN SUBUNIT THAT MEDIATE BACTERIAL-COLONIZATION, Gene, 192(1), 1997, pp. 79-85
Citations number
28
Categorie Soggetti
Genetics & Heredity
Journal title
GeneACNP
ISSN journal
03781119
Volume
192
Issue
1
Year of publication
1997
Pages
79 - 85
Database
ISI
SICI code
0378-1119(1997)192:1<79:DWTVTC>2.0.ZU;2-7
Abstract
Several experimental approaches have provided evidence suggesting that a domain within the C-terminal region of the TcpA pilin, delineated b y the single disulfide loop, is directly responsible for the colonizat ion function mediated by the toxin coregulated pilus (TCP) of Vibrio c holerae. This evidence includes the mapping of domains recognized by p rotective monoclonal antibodies to this region, the ability of peptide s from within this region to elicit cholera protective antibody, the c onstruction of tcpA missense mutations that abolish TCP function, and the requirement of a periplasmic disulfide isomerase to produce functi onal TCP. (C) 1997 Elsevier Science B.V.