On the basis of Gortel & Grendel (J. Exp. Med., 1925, 41, 439-494) discover
y, the importance of the lipid bilayer as an integral and indispensible com
ponent of the cell membrane is discussed. In particular, attention focuses
on the interaction between membranes and amphiphilic substances. The effect
on membranes of quaternary ammonium salts, both in the form of pesticides
and oxidants as well as organic com pounds of tin and lead are discussed in
greater detail.