Isaacs' syndrome successfully treated by immunoadsorption plasmapheresis

We report a 70-year-old woman with Isaacs' syndrome (acquired neuromyotonia ) who showed a marked improvement after immunoadsorption plasmapheresis (IA P). She developed hyperhidrosis in her teens, We report a 70-year-old woman with Isaacs' syndrome (acquired and slowly progressive symptoms of neuromy otonia for over 50 years. An in vitro investigation of her serum with patch -damp technique suggested the presence of antibodies against potassium chan nels. She was treated with IAP, which brought disappearance of her symptoms . Though the symptoms started to recur in 3 weeks, moderate improvement has been maintained by immunosuppressive drug treatment.