H. Bidoggia et al., Sex differences on the electrocardiographic pattern of cardiac repolarization: Possible role of testosterone, AM HEART J, 140(4), 2000, pp. 678-683
Citations number
16
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Background Cardiac repolarization has been shown to be shorter and faster i
n men compared with women. In this study, we examined the electrocardiograp
hic pattern of repolarization in patients with abnormal plasma levels of te
stosterone to gain insight into the role that this hormone plays in modulat
ing repolarization.
Methods and Results Repolarization was measured in 27 castrated men, 26 wom
en with virilization, and 53 control subjects pair-matched for age and sex.
Repolarization in castrated men was slower and longer than that of normal
men. Women with virilization exhibited a shorter and faster repolarization
than normal women and castrated men. These differences are the opposite of
those found in the normal population. Finally, the changes observed in cast
rated men may be reverted by testosterone.
Conclusions We conclude that testosterone plays an important role in modula
ting cardiac repolarization.