Choroidal neovascularization with granulomatous inflammation in ocular histoplasmosis syndrome

PURPOSE: To report pathologic examination of an excised choroidal neovascul ar membrane in a patient with ocular histoplasmosis syndrome that demonstra ted granulomatous inflammation. METHOD: Case report. A 50-year-old woman with sudden vision loss in her lef t eye demonstrated clinical and fluorescein angiographic findings character istic of choroidal neovascularization secondary to ocular histoplasmosis sy ndrome. RESULTS: Histopathologic examination of the surgically excised choroidal ne ovascular membrane disclosed granulomatous inflammation. CONCLUSIONS: This case suggests an important role of mononuclear phagocytic cells as primary mediators of angiogenesis or modifiers of choroidal neova scularization. This association of choroidal neovascularization with granul omatous inflammation did not respond to treatment with systemic corticoster oids. (C) 2000 by Elsevier Science Inc. All rights reserved.