Neck abscess located in or around the thyroid gland should raise the suspic
ion of acute suppurative thyroiditis, pyriform sinus fistula, a 3rd or 4th
branchial cleft anomaly. Differentiating between these entities on a clinic
al basis is difficult. After treating the initial infection, computed tomog
raphy, barium esophagography, ultrasound, and endoscopy can be used in sear
ch of the fistulous tract that can be associated with a pyriform sinus fist
ula or a 3rd or 4th branchial anomaly. We present a case of a pyriform sinu
s fistula involving the use of oral contrast, combined with computed tomogr
aphy, to delineate the tract and its surrounding structures. This method, i
n combination with endoscopy, aided in the removal of this branchial anomal
y.