Evaluation of a cerebral oximeter as a monitor of cerebral ischemia duringcarotid endarterectomy

Background: Stroke is an important contributor to perioperative morbidity a nd mortality associated with carotid endarterectomy (CEA). This Investigati on was designed to compare the performance of the INVOS-3100 cerebral oxime ter to neurologic function, as a means of detecting cerebral ischemia Induc ed by carotid cross-clamping, in patients undergoing carotid endarterectomy with cervical plexus block. Methods: Ninety-nine patients undergoing 100 CEAs with regional anesthesia (deep or superficial cervical plexus block) were studied, Bilateral regiona l cerebrovascular oxygen saturation (rsO(2)) was monitored using the INVOS- 3100 cerebral oximeter. Patients were retrospectively assigned to one of tw o groups: those In whom a change in mental status or contralateral motor de ficit was noted after internal carotid clamping (neurologic symptoms; n = 1 0) and those who did not show any neurologic change (no neurologic symptoms ; n = 90), Data from 94 operations (neurologic symptoms = 10 and no neurolo gic symptoms = 84) were adequate for statistical analyses for group compari sons. A relative decrease in ipsilateral rSO(2) after carotid occlusion (ca lculated as a percentage of preocclusion value) during all operations (n = 100) was also calculated to determine the critical level of rSO(2) decrease associated with a change in neurologic function. Results: The mean (+/- SD) decrease in rSO(2) after carotid occlusion in th e neurologic symptoms group (from 63.2 +/- 8.4% to 51.0 +/- 11.6%) was sign ificantly greater (P = 0.0002) than in the no neurologic symptoms group (fr om 65.8 +/- 8.5% to 61.0 +/- 9.3%) Logistic regression analysis used to det ermine if a change in rSO(2), calculated as a percentage of preclamp value, could be used to predict change in neurologic function was highly signific ant (likelihood ratio chi-square = 13.7; P = 0.0002). A 20% decrease in rSO (2) reading from the preclamp baseline, as a predictor of neurologic compro mise, resulted In a sensitivity of 80% and specificity of 82.2%. The false- positive rate using this cutoff point was 66.7%, and the false-negative rat e was 2.6%, providing a positive predictive value of 33.3% and a negative p redictive value of 97.4%. Conclusion: Monitoring rSO(2) with INVOS-3100 to detect cerebral ischemia d uring CEA has a high negative predictive value, but the positive predictive value is low.