Systolic murmurs were detected in 22 (61%) of the 36 children with sickle c
ell anaemia (SCA) who completed the study. Cardiomegaly was detected in 14
(39%). Mean values of left and right ventricular dimensions were higher in
SCA than in controls (p<0.05). Left atrial chambers and aortic root dimensi
ons followed the same pattern. The dilated cardiac chambers in SCA were not
associated with any abnormality in systolic or diastolic left ventricular
function nor with significant pulmonary hypertension.