Pharmacodynamic study of low molecular weight dermatan sulphate (Desmin) after a single subcutaneous administration in patients with renal insufficiency

The pharmacodynamic pattern of low molecular weight dermatan sulphate (CAS 24967-94-0, Desmin-LMWDS) was studied in patients presenting chronic renal insufficiency. Three groups of six patients were defined according to their creatinine clearance: group 1, more than 50 ml/ min, group 2 between 10 an d 50 ml/min and group 3 lower than 10 ml/min (haemodialized patients). Desm in-LMWDS concentrations were determined with the Heptest assay and the chro mogenic specific heparin cofactor II dependent anti IIa assay. In patients of group 1 affected by moderate renal insufficiency, the pharmacodynamic pr ofiles were roughly comparable to those obtained in normal subjects. In the two other groups, the profiles were markedly modified by the renal insuffi ciency. The maximal concentrations were doubled and the areas under the tim e-activity curve were 4-fold higher in haemodialyzed (group 3) and severe r enal insufficient patients (group 2) than in patients of group 1. The clear ance of the anti IIa activity were 13.98 +/- 6.25 l/h; 4.12 +/- 2.64 l/h an d 2.94 +/- 1,53 l/h and the half-lives were 2.79 +/- 2.60 h, 6.15 +/- 4.02 h and 11.51 +/- 6.54 h in groups 1 to 3, respectively (p < 0.05). The Desmi n-LMWDS clearance was directly correlated to the creatinine clearance (r = 0.8244, n = 18, p < 0.001). Thus, as for low molecular weight heparin, rena l function plays a major role in the elimination of low molecular weight de rmatan sulphate.