One-month safety study of intraperitoneal VRCTC-310-Onco (crotoxin plus cardiotoxin) in rats

Authors
Stanchi, NO Arias, D Bartolucci, E Martino, PE Gimeno, EJ Diez, RA Costa, LA
Citation
No. Stanchi et al., One-month safety study of intraperitoneal VRCTC-310-Onco (crotoxin plus cardiotoxin) in rats, ARZNEI-FOR, 50(9), 2000, pp. 862-866
Citations number
36
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
ISSN journal
00044172 → ACNP
Volume
50
Issue
9
Year of publication
2000
Pages
862 - 866
Database
ISI
SICI code
0004-4172(200009)50:9<862:OSSOIV>2.0.ZU;2-O
Abstract
To evaluate the toxicity of VRCTC-310-Onco (Crotalus durissus terrificus cr otoxin + cardiotoxin from Naja naja atra), 10 Sprague-Dawley rats were impl anted with intraperitoneal slow-release devices and subjected to treatment with 0.5 mu g/g body weight/d for 14 days. Biochemical evidence at days 7 a nd 14 showed blood, muscular, renal and metabolic disturbance, mostly rever sed by day 28. No significant changes were found in necropsy. The limited t oxicity of IP VRCTC-310-Onco in rats deserves further study.