This paper develops a practical approach to diagnosing the existence of a l
atent stochastic process in the mean of a Poisson regression model. The asy
mptotic distribution of standard generalised linear model estimators is der
ived for the case where an autocorrelated latent process is present. Simple
formulae for the effect of autocovariance on standard errors of the regres
sion coefficients are also provided. Methods for adjusting for the severe b
ias in previously proposed estimators of autocovariance are derived and the
ir behaviour is investigated. Applications of the methods to time series of
monthly polio counts in the U.S.A. and daily asthma presentations at a hos
pital in Sydney are used to illustrate the results and methods.