Chemoenzymatic synthesis of L-galactosylated dimeric sialyl Lewis X structures employing alpha-1,3-fucosyltransferase V

Authors
Duffels, A Green, LG Lenz, R Ley, SV Vincent, SP Wong, CH
Citation
A. Duffels et al., Chemoenzymatic synthesis of L-galactosylated dimeric sialyl Lewis X structures employing alpha-1,3-fucosyltransferase V, BIO MED CH, 8(10), 2000, pp. 2519-2525
Citations number
26
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
09680896 → ACNP
Volume
8
Issue
10
Year of publication
2000
Pages
2519 - 2525
Database
ISI
SICI code
0968-0896(200010)8:10<2519:CSOLDS>2.0.ZU;2-S
Abstract
L-Galactosylated dimeric sialyl Lewis X (SLe(x)) has been prepared employin g a combination of chemical and enzymatic synthetic methods. GDP-L-galactos e has been chemically synthesised. Enzymatic transfer of L-galactose onto t he acceptor (Sia-alpha 2,3-Gal-beta 1,4-GlcNAc-beta 1,3/6)(2)-Man-alpha 1-O Me was achieved using the human alpha-1,3-fucosyltransferase V. (C) 2000 El sevier Science Ltd. All rights reserved.