Design, synthesis, and discovery of 3-piperazinyl-3,4-dihydro-2(1H)-quinolinone derivatives: A novel series of mixed dopamine D-2/D-4 receptor antagonists

Authors
Zhao, H Thurkauf, A Braun, J Brodbeck, R Kieltyka, A
Citation
H. Zhao et al., Design, synthesis, and discovery of 3-piperazinyl-3,4-dihydro-2(1H)-quinolinone derivatives: A novel series of mixed dopamine D-2/D-4 receptor antagonists, BIOORG MED, 10(18), 2000, pp. 2119-2122
Citations number
31
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
18
Year of publication
2000
Pages
2119 - 2122
Database
ISI
SICI code
0960-894X(20000918)10:18<2119:DSADO3>2.0.ZU;2-5
Abstract
3-Piperazinyl-3,4-dihydro-2(1H)-quinolinone derivatives (delta-lactams) wer e designed, synthesized, and identified as a new series of mixed dopamine D -2/D-4 receptor antagonists. To further the structure-activity relationship (SAR) study, 3-piperazinylindolin-2-ones (gamma-lactams) and 3-piperazinyl -3H,4H,5H-benzo[f]azepin-2-ones (E-lactams) were also prepared and examined . (C) 2000 Elsevier Science Ltd. All rights reserved.