Synthesis and antibacterial activities of novel C(3)-aminopyrimidinyl substituted cephalosporins including against respiratory tract pathogens

Authors
Lee, CS Ryu, EJ Oh, SH Paek, KS Kim, MY Youn, H
Citation
Cs. Lee et al., Synthesis and antibacterial activities of novel C(3)-aminopyrimidinyl substituted cephalosporins including against respiratory tract pathogens, BIOORG MED, 10(18), 2000, pp. 2123-2127
Citations number
8
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
18
Year of publication
2000
Pages
2123 - 2127
Database
ISI
SICI code
0960-894X(20000918)10:18<2123:SAAAON>2.0.ZU;2-X
Abstract
The variety of cephalosporins 1 and 2 which possessed C(3)-aminopyrimidinyl substituents were prepared and evaluated for their antibacterial activitie s. They exhibited excellent in vitro activities especially against respirat ory tract pathogens such as penicillin resistant Streptococus pneumonia, Mo raxella catarrhalis and Haemophilus influenza. (C) 2000 Elsevier Science Lt d. All rights reserved.