2-nitro analogues of adenosine and 1-deazaadenosine: Synthesis and bindingstudies at the adenosine A(1), A(2A) and A(3) receptor subtypes

Authors
Wanner, MJ Kunzel, JKVD IJzerman, AP Koomen, GJ
Citation
Mj. Wanner et al., 2-nitro analogues of adenosine and 1-deazaadenosine: Synthesis and bindingstudies at the adenosine A(1), A(2A) and A(3) receptor subtypes, BIOORG MED, 10(18), 2000, pp. 2141-2144
Citations number
21
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
18
Year of publication
2000
Pages
2141 - 2144
Database
ISI
SICI code
0960-894X(20000918)10:18<2141:2AOAA1>2.0.ZU;2-A
Abstract
The influence of nitro substituents on the properties of adenosine and 1-de azaadenosine was studied. Combination of a nitro group at the 2-position wi th several N-6 substituents such as cyclopentyl and m-iodobenzyl gave a ser ies of analogues with good adenosine receptor affinity, showing directable selectivity for the A(1), A(2A) and A(3) adenosine receptor subtypes. (C) 2 000 Elsevier Science Ltd. All rights reserved.