Synthesis and biological evaluation of L- and D-configuration 1,3-dioxolane 5-azacytosine and 6-azathymine nucleosides

Authors
Luo, MZ Liu, MC Mozdziesz, DE Lin, TS Dutschman, GE Gullen, EA Cheng, YC Sartorelli, AC
Citation
Mz. Luo et al., Synthesis and biological evaluation of L- and D-configuration 1,3-dioxolane 5-azacytosine and 6-azathymine nucleosides, BIOORG MED, 10(18), 2000, pp. 2145-2148
Citations number
16
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
18
Year of publication
2000
Pages
2145 - 2148
Database
ISI
SICI code
0960-894X(20000918)10:18<2145:SABEOL>2.0.ZU;2-I
Abstract
Novel L- and D-configuration dioxolane 5-azacytosine and 6-azathymine nucle osides have been synthesized and evaluated for biological activity. (-)-(2S ,4S)- 1-[2-(Hydroxymethyl)-1,3-dioxolan-4-yl]-5-azacytosine (6) showed sign ificant activity against HBV, whereas the D-configuration analogue (14) has been found to exhibit potent anti-HIV activity. (C) 2000 Elsevier Science Ltd. All rights reserved.