Development of squamous cell carcinoma by two high-risk human papillomaviruses (HPVs), a novel HPV-67 and HPV-31 from bowenoid papulosis

We report a patient with bowenoid papulosis (BP) involving two high-risk hu man papillomaviruses (HPVs) and the development of invasive squamous cell c arcinoma (SCC), Our patient showed verrucous lesions on the penis, perianal area and groin that had been noted over the previous 8 years and had recur red after all therapeutic approaches. The perianal and left inguinal lesion s revealed invasive SCC on histology. HPV-31 and HPV-67 sequences were dete cted by polymerase chain reaction from BP lesions of the perianal area and the shaft of the penis. HPV-31 has already been reported in BP as a high-ri sk HPV for the development of SCC, but HPV-67 is a novel one that has never been reported in BP. As HPV-67 has sequence homology to HPV-52 and HPV-58, it belongs to the family of HPV-16, a high-risk HPV group. Thus our patien t showed two high-risk. HPVs, i.e. HPV-31 and the novel HPV-67, which may b e directly involved in the development of SCC.