Incidence of the preconceptional management of type 1 diabetes on the outcome of pregnancy

Foetal mortality and morbidity remain dramaticaly increased in diabetic wom en. To evaluate the benefit of a preconceptional education combined with a good metabolic control, we compared the outcome of pregnancy in 2 groups of type I diabetic women: group A (n=21) planned before conception versus gro up B (n=40) not planned. Both groups were similar related to the type and d uration of diabetes, its complications, age, body mass index and different factors of risk. In group A, HbA1C levels were less than or equal to 3 SD o f the normal mean of non diabetic values before conception and during the p regnancy course and greater than or equal to 3 SD in group B. We observed a significant reduction (p<0.05) of the main adverse events regarding foetus outcome (foetal, perinatal and neonatal mortality, malformations) and obst etrical complications in the planned group. These data lead to the need of an extensive policy of early planification of pregnancy in diabetic women.