Characterization of prochirality and classification of meso-compounds by means of the concept of size-invariant subductions

The concept of size-invariant subductions has been proposed to design proch iral molecules. Thus, an even-membered homospheric orbit has been proved to be desymmetrized into an enantiospheric orbit, where the sizes of the rele vant orbits remain invariant. The concept has been applied to methanes, all enes, adamantanes, and biphenyls. It has proved effective in designing a wi de variety of prochiral molecules. These prochiral molecules have been show n to be extrinsic meso compounds. Intrinsic meso compounds have also been d iscussed as another type of prochiral molecule.