Possible conformations and relative stability of the 7-membered ring in 1 alpha 5 beta,6,7 alpha(H)- and 1 beta,5 alpha,6,7 alpha(H)-guai-11(13)-en-6,12-olides

Authors
Fazylova, AS Turdybekov, KM
Citation
As. Fazylova et Km. Turdybekov, Possible conformations and relative stability of the 7-membered ring in 1 alpha 5 beta,6,7 alpha(H)- and 1 beta,5 alpha,6,7 alpha(H)-guai-11(13)-en-6,12-olides, CHEM NAT CO, 36(1), 2000, pp. 68-71
Citations number
8
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
CHEMISTRY OF NATURAL COMPOUNDS
ISSN journal
00093130 → ACNP
Volume
36
Issue
1
Year of publication
2000
Pages
68 - 71
Database
ISI
SICI code
0009-3130(200001/02)36:1<68:PCARSO>2.0.ZU;2-5
Abstract
Stereoisomers of 1 alpha,5 beta,6,7 alpha(H)- and 1 beta,5 alpha,6,7 alpha( H)-guai-11(13)-en-6,12-olides are calculated using molecular mechanics. The possibility of forming various conformations in the 7-membered ring is exa mined as a function of the fusion to the 5-membered C-ring. The effect of t he methyl orientation on the conformation of the 7-membered ring and the re lative stability of the conformers are discussed.