Histopathological and biochemical changes in the sutural region in craniosynostosis

Object: Histopathological observations and biochemical analysis of sutural bones in nine patients with craniosynostosis were compared with control sub jects of the same age range. Methods: Microscopic examination in craniosyno stosis showed formation of an active osseous front, with higher osteoblasti c activity than in controls. Biochemical analysis revealed higher calcium, phosphorus, alkaline phosphatase, phospholipids and chondroitin sulphate-A contents in sutural bones of the same patients. Conclusions: The present st udy systematically establishes a premature increase in osteogenesis in the sutures of craniosynostosis patients.