This article describes the rationale and current research on Systematic Tre
atment Selection, a method for matching and fitting inter ventions to patie
nts and patient problems. An efficient method of treatment Planning must no
t only use effective and empirically tested procedures, but should take int
o account the fit of these procedures with important nondiagnostic informat
ion about the patient, and aspects of the patient's environment. The effort
to transfer research-based treatment manuals to clinical practice has ofte
n failed because it requires therapists to give up procedures and theories
that have been accepted on the basis of clinical experience and fails to co
nsider ways in which patient qualities affect the fit of the treatment. Sys
tematic Treatment Selection and its derivative, Pre scriptive Therapy seeks
to overcome these difficulties by empirically defining general principles
of treatment intervention and selection that cut across therapist theoretic
al orientation and capitalize on the selection and use of methods that are
favored by the clinician.