R. Seoane et al., Study of the interaction of cholesterol with potentially hypocholesterolemic substances in a monolayer form, COLL SURF A, 174(3), 2000, pp. 329-340
Citations number
46
Categorie Soggetti
Physical Chemistry/Chemical Physics
Journal title
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
The behaviour of mixed monolayers of cholesterol (chol) and stigmastanil ph
osporylcholine (SPC) at the air-water interface was studied and compared wi
th that of the cholesterol-arachidonic acid (Ara) system in order to examin
e the molecular interactions between the film components. The structural ch
aracteristics of the mixed films was determined from the pi-A isotherms rec
orded on an automated Langmuir-type film balance. The studies confirm that
the mixed films are homogeneous and their components exhibit negative devia
tions from ideality as the result of mutual interactions at the interface.
The magnitude of these interactions depends on the surface pressure region,
temperature, as well as the system composition. Values of the thermodynami
c parameters such as Delta G(exc), Delta S-exc and Delta H-exc provide evid
ence for the presence of interactions, which are stronger in the chol-SPC s
ystem than in the chol-Ara mixed films. (C) 2000 Elsevier Science B.V. All
rights reserved.