An approach for the estimation of drug prescribing using the defined dailydose methodology and drug dispensation data - Theoretical considerations and practical applications
M. Cosentino et al., An approach for the estimation of drug prescribing using the defined dailydose methodology and drug dispensation data - Theoretical considerations and practical applications, EUR J CL PH, 56(6-7), 2000, pp. 513-517
Objective: To test the hypothesis that comparison of defined daily dose (DD
D) and drug user data may help to estimate drug exposure in a defined popul
ation and provide information about drug prescribing patterns.
Methods and results: First, comparison of DDD figures with the number of ap
parent drug users (ADU, i.e., individuals for whom at least one prescriptio
n of the drug had been dispensed during a given time period) is demonstrate
d to correspond to the product of the prescribed daily dose (PDD) and the p
roportion of days in which the drug had been taken (days of treatment/days
in a time period, D). The resulting equation (DDD/day)/ADU in a time period
= PDD x D is then applied to the analysis of different sets of drug dispen
sation data. Examples show that this approach may be helpful to monitor dru
g prescribing patterns over time. Moreover, in definite situations, it may
provide reliable estimates of either PDD or D.
Conclusions: Comparison of DDD and drug user data is suggested to be a cost
-effective strategy to monitor drug prescribing patterns from an epidemiolo
gical perspective, which may be useful to researchers involved in drug util
isation studies as well as to health authorities for monitoring and regulat
ory purposes.