Ultrasound variables and their prognostic value in a population of 1103 patients with 272 breast cancers

In a prospective two-centre study targeted US was performed as an adjunct t o mammography in a population of 1103 patients with 272 breast cancers, 517 benign lesions and no abnormalities in 314 patients. The purpose of the st udy was to analyse the distribution of the different US variables among the breast lesions and to determine the prognostic value; of these variables w ith respect to the diagnosis of malignancy. The following variables were an alysed: border; contour; orientation; structure; echogenicity I sound trans mission; and size. These variables were correlated with the definitive diag nosis and univariate analysis was performed. A statistically significant as sociation with breast cancer (p < 0.001) was present for irregular border; ill-defined contour; indeterminate or vertical orientation; homogeneous, co mplex or heterogeneous structure; hypoechogenicity; and unchanged or decrea sed sound transmission. Multivariate analysis showed a high independent pro gnostic value for malignancy for irregular border, followed by ill-defined contour and unchanged or decreased sound transmission. However, their discr iminative power was not absolute: in 38 cancers none of : the malignant US variables were present, and in 11 benign lesions all variables were present . There were hardly any benign-looking lesions that proved to be malignant.