The effects of caulophyllum D4 on the spontaneous contractile activity of smooth muscle

Objective: In a randomised, double-blind, placebo-controlled study, no clin ical efficacy of Caulophyllum D4 could be shown with 40 pregnant women with premature amnion rupture. It was the aim of this study to confirm the resu lts of this clinical trial by basic research. Therefore the effects of Caul ophyllum D2-D6 on the spontaneous contractile activity (SCA) of smooth musc le fibres of uterus have been measured in vitro. Methods: The spontaneous contraction activity of the smooth muscles and the influence of the homeopathic dilutions were registrated by tension transdu cers under isometric conditions. Results: The homeopathic dilutions D2-D6 did not cause myogene effects. Conclusions: It can be said that Caulophyllum D2-D6 did not show an increas e of SCA of the smooth muscles. The clinical efficacy, however, could not b e proved. The clinical and in-vitro investigations confirm each other. Caul ophyllum D4 can be prescribed for pregnant women with premature amnion rupt ure without fear of side effects, although the efficacy could not be proved in the clinical trial and the basic research work. Before homeopathic trea tment can be used in the delivery room, it must first meet the same criteri a as standard medical treatment.