Age-specific survival of women with endometrioid adenocarcinoma of the uterus

Objective. The purpose of this paper was to evaluate the age-specific survi val for women diagnosed with endometrioid adenocarcinoma of the uterus. Methods. A retrospective analysis was conducted of 328 patients diagnosed w ith endometrioid adenocarcinoma of the uterus between January 1990 and Dece mber 1997. Patients were followed for 3 to 96 months with a mean of 43 mont hs. The impact of age on survival was assessed using Col proportional hazar d regression and multivariate analysis for age, stage, and grade. Stage and grade were analyzed using log-rank tests, and survival curves were generat ed by the Kaplan-Meier method. Results. A total of 328 patients were evaluated. Multivariate analysis reve aled age, stage, and grade were all significant independent predictors of s urvival (P < 0.0001). Age-specific survival varied from a high of 90% at ag e 40 to a low of 55% at age 80. interval age-specific survival decreased be low 86% at age 50. Subset analysis of patients younger than 50 compared wit h older patients revealed no difference in surgical stage or grade of tumor s among these patients. Patients older than 50, however, were 41% more like ly to receive adjuvant radiation therapy. Conclusion. Age is a specific, significant predictor of outcome in endometr ioid adenocarcinoma of the uterus. Survival decreases significantly in pati ents older than 50. This decreased survival associated with age is unrelate d to surgical stage or grade of adenocarcinoma, Decreased survival could in volve molecular differences in the developing endometrial cancer or an incr eased risk of death from other non-cancer-related factors, (C) 2000 Academi c Press.