Angiosarcoma of the frontal sinus. Case report and review of the literature

Angiosarcomas are very rare but highly malignant soft tissue tumors derived from the vascular endothelium. The tumor is most commonly found in the ski n. The cancer is known to cause early and widespread metastases leading to a very poor prognosis of less than 24 months. The therapy of choice is radi cal surgery followed by adjuvant radiation. In this case study, we report on a patient with a very unusual localization of angiosarcoma in the frontal sinus. Based on this case,we discuss import ant aspects of tumor biology, diagnostic procedures, and histologic feature s as well as therapeutic options. We conclude that angiosarcoma has to be considered by a differential diagno sis in all head and neck neoplasias with uncertain histology.