E. Rintala et al., Bactericidal/permeability-increasing protein (BPI) in sepsis correlates with the severity of sepsis and the outcome, INTEN CAR M, 26(9), 2000, pp. 1248-1251
Objective: To compare the prognostic significance of bactericidal/permeabil
ity-increasing protein (BPI), group II phospholipase A(2) (PLA(2)-II), C-re
active protein (CRP), tumour necrosis factor-ex (TNF), interleukin-8 (IL-8)
and interferon-gamma (IFN) in terms of predicting severity of sepsis and o
utcome.
Design: A prospective study.
Setting:. Medical intensive care unit (UCI) of a university hospital. Patie
nts: Thirty-four patients with severe sepsis requiring ICU treatment.
Measurements and results: The levels of BPI, PLA(2)-II, CRP, TNF, IL-8 and
IFN were measured in these 34 patients. High levels of BPI were associated
particularly with Gram-negative sepsis. BPI and BPI/neutrophil ratios corre
lated positively with PLA(2)-II, CRP, TNF and IL-8 and negatively with bloo
d pressure. At 24 h, BPI/neutrophil ratios. IL-8 and Simplified Acute Physi
ology Scores II (SAPS II) scores were higher in non-survivors than in survi
vors. No such associations were noted in the levels of CRP, PLA(2)-II, TNF
or IFN. The areas under the curve (AUCROCs) of SAPS II scores and IL-8 were
higher than AUC(ROC) of BPI/neutrophil ratio.
Conclusion: The BPI and BPI/neutrophil ratios may serve as adjunctive tools
to illustrate the severity of sepsis. However, their predictive power for
sepsis-related death was not comparable to that of SAPS II scores and IL-8.