CYTOMEGALOVIRUS (CMV) CULTURE RESULTS, DRUG-RESISTANCE, AND CLINICAL OUTCOME IN PATIENTS WITH AIDS AND CMV RETINITIS TREATED WITH FOSCARNETOR GANCICLOVIR

Authors
LEWIS RA CLOGSTON P FAINSTEIN V GROSS R SAMO T TUTTLE C JABS DA APUZZO L BARTLETT J COLESON L DUNN JP ELDRED L FEINBERG J FLYNN T KING R LESLIE J BARRON B GREENSPAN D LECOUNT C PEYMAN G FRANKLIN R HEINEMANN MH POLSKY B SQUIRES K WISECAMPBELL S FRIEDMAN AH CHEUNG AW JUSTIN N TEICH S SACKS H SEVERIN C FRIEDBERG DN ADDESSI A DIETERICH D FROST K WEINBERG D JAMPOL L MURPHY R NAUGHTON K HENDERLY D HOLLAND GN CHAFEY S FALL H HARDY WD KIMBRELL C MACARTHURCHANG L FREEMAN WR MEIXNERT L PETERSON TJ QUICENO JI RICKMAN L SIMANELLO MA SPECTOR S ODONNELL J HOFFMAN J IRVINE A JACOBSON M LARSON J SEIFF S WANNER M DAVIS J CHUANG E ESPINAL M MENDEZ P VANDENBROUCKE R DODGE JM STEVENS M BROWNBELLAMY J KLEMM AC MARKOWITZ JA WEBB R MEINERT CL AMENDLIBERCCI D COLESONSCHREUR L COLLINS KL COLLISON BJ DODGE J DONITHAN M FINK N KAPLANGILPIN AM GERCZAK C HOLBROOK JT ISAACSON MR LANE MF LEVINE CR MARTIN BK MIN YI OWENS RM NOWAKOWSKI DJ SAAH A TONASCIA J VANNATTA ML DAVIS MD AGRESSEGAL M ARMSTRONG J BROTHERS R FREITAG G HUBBARD L HURLBURT D KASTORFF L MAGLI Y MINER K THOMAS S VANDERHOOFYOUNG M DREW WL MINOR R STEWART G HUGHES R WELCH L MOWERY R ELLENBERG S KORVICK J SATTLER F BROWN BW CONWAY B GRIZZLE J NUSSENBLATT R PHAIR J SMITH H WHITLEY R
Citation
Ra. Lewis et al., CYTOMEGALOVIRUS (CMV) CULTURE RESULTS, DRUG-RESISTANCE, AND CLINICAL OUTCOME IN PATIENTS WITH AIDS AND CMV RETINITIS TREATED WITH FOSCARNETOR GANCICLOVIR, The Journal of infectious diseases, 176(1), 1997, pp. 50-58
Citations number
27
Categorie Soggetti
Infectious Diseases
Journal title
The Journal of infectious diseases → ACNP
ISSN journal
00221899
Volume
176
Issue
1
Year of publication
1997
Pages
50 - 58
Database
ISI
SICI code
0022-1899(1997)176:1<50:C(CRDA>2.0.ZU;2-G
Abstract
The objectives of the study were to examine the clinical significance of cytomegalovirus (CMV) culture results and drug susceptibilities in CMV isolates from patients with AIDS-related CMV retinitis, Blood and urine for CMV culture were obtained from 207 patients with newly diagn osed CMV retinitis who were enrolled in a randomized trial comparing f oscarnet and ganciclovir. Culture-positive rates at baseline were 45% and 71% for blood and urine, respectively. Rates decreased 3- to 10-fo ld after initiation of either treatment. Mortality was related to both positive baseline blood and urine cultures; adjusted relative risks w ere 1.97 and 2.03, respectively, Positive blood cultures at baseline w ere associated with more rapid retinitis progression. Drug-resistant C MV was found, over comparable follow-up periods on assigned treatment, in 4 of 8 ganciclovir-assigned patients with persistent viremia and 0 of 5 foscarnet-assigned patients with persistent viremia, Results of virologic assays of blood appear to be associated with clinical outcom e of CMV retinitis.