Glial cell line-derived neurotrophic factor (GDNF) as a defensive moleculefor neurodegenerative disease: a tribute to the studies of Antonia Vernadakis on neuronal-glial interactions

Authors
Bohn, MC Kozlowski, DA Connor, B
Citation
Mc. Bohn et al., Glial cell line-derived neurotrophic factor (GDNF) as a defensive moleculefor neurodegenerative disease: a tribute to the studies of Antonia Vernadakis on neuronal-glial interactions, INT J DEV N, 18(7), 2000, pp. 679-684
Citations number
43
Categorie Soggetti
Neurosciences & Behavoir
Journal title
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
ISSN journal
07365748 → ACNP
Volume
18
Issue
7
Year of publication
2000
Pages
679 - 684
Database
ISI
SICI code
0736-5748(200011)18:7<679:GCLNF(>2.0.ZU;2-Q
Abstract
Research stemming from interests in neuronal-glial interactions has led to the identification of a number of novel trophic factors. such as the dopami nergic neurotrophic factor glial cell line-derived neurotrophic factor (GDN F). Delivery of the GDNF gene to rat models of Parkinson's disease suggests a potential clinical use of GDNF gene therapy for humans with this disease . This review article briefly summarizes the history of GDNF and the effect s of GDNF gene delivery prior to or after a lesion of the rat nigrostriatal system. (C) 2000 ISDN. Published by Elsevier Science Ltd. All rights reser ved.