Review of intraurethral suppositories and iontophoresis therapy for erectile dysfunction

This brief review examines the history of the intraurethral (IU) pharmacoth erapy for the treatment of erectile dysfunction (ED). Emphasis is placed on the design, study endpoints and results of a limited number of clinical tr ials undertaken with PGE(1)-MUSE to demonstrate the efficacy of this unique delivery system. Next, the theory of the iontophoretic technique of drug d elivery is discussed. Clinical data collected while applying these methods are presented, but are thus far limited to treatment of patients with Peyro nie's disease. Iontophoresis as a drug delivery alternative may gain popula rity with ED patients who fail other types of therapy or in patients with o ther penile disorders.