Application of acoustic emission to the monitoring and end point determination of a high shear granulation process

Authors
Whitaker, M Baker, GR Westrup, J Goulding, PA Rudd, DR Belchamber, RM Collins, MP
Citation
M. Whitaker et al., Application of acoustic emission to the monitoring and end point determination of a high shear granulation process, INT J PHARM, 205(1-2), 2000, pp. 79-91
Citations number
7
Categorie Soggetti
Pharmacology & Toxicology
Journal title
INTERNATIONAL JOURNAL OF PHARMACEUTICS
ISSN journal
03785173 → ACNP
Volume
205
Issue
1-2
Year of publication
2000
Pages
79 - 91
Database
ISI
SICI code
0378-5173(20000915)205:1-2<79:AOAETT>2.0.ZU;2-Y
Abstract
The application of a novel monitoring technique, based on the use of acoust ic emissions. is reported for a model high shear granulation process. It ha s been demonstrated that this technique is capable of monitoring changes in physical properties of powder material during granulation (particle size, flow properties and compression properties). The technique is non-invasive, sensitive and relatively inexpensive. (C) 2000 Elsevier Science B.V. All r ights reserved.