S. Priolo et al., Effects of experimentally induced ametropia on the morphology and optical quality of the avian crystalline lens, INV OPHTH V, 41(11), 2000, pp. 3516-3522
PURPOSE. TO examine the effects of refractive error on avian lens morpholog
y and optical quality.
METHODS. Hatchling white leghorn chicks were unilaterally goggled for 7 day
s with either a form-deprivation goggle (n = 12), a -10 D defocus goggle Oz
= 12), or a +10 D defocus goggle (n = 12) to induce myopia and hyperopia.
Optical quality of lenses (focal length and focal length variability) from
treated and contralateral control eyes was assessed using a scanning laser
apparatus. Lens morphology was examined by light and electron microscopy.
RESULTS. Although the induction of refractive errors did not significantly
alter lens size, shape, paraxial focal length, or average focal length, ave
rage focal length variability increased. Lenses from eyes goggled with form
-deprivation and +10 D defocus goggles demonstrated a twofold increase in a
verage focal length variability, when compared with their contralateral con
trols. The morphology of the lens is not altered by these experimental mani
pulations.
CONCLUSIONS. This study provides evidence that the refractive development o
f the chick lens is not independent of the refractive development of the oc
ular globe and that chick lenticular development is influenced by both gene
tics and visual experience.