Purpose: To study the association between after-cataract and secondary glau
coma after lensectomy and 5-fluorouracil treatment in an experimental infan
t rabbit model.
Setting: St Erik Eye Hospital, Karolinska institute, Stockholm, Sweden.
Methods: Lensectomy was performed in both eyes of 16 3-week-old rabbits. On
e randomly selected eye in each rabbit was injected with 2.5 mg of 5-fluoro
uracil (5-FU) at surgery and 5.0 mg the day after surgery to reduce the for
mation of after-cataract. Axial length, corneal thickness, corneal diameter
, and intraocular pressure were measured preoperatively and 4 times during
the 6 months following surgery. Six months after surgery, the wet weight of
the after-cataract was determined.
Results: in 16 aphakic eyes treated with 5-FU, no or a minimal amount (< 0.
001 g) of after-cataract developed. None of the eyes showed signs of second
ary glaucoma. Of 16 aphakic eyes not treated with 5-FU, 10 developed consid
erable amounts of after-cataract (>0.10 g); 8 of these developed glaucoma.
The other 6 eyes had no or minimal after-cataract and did not develop secon
dary glaucoma. The relationship between after-cataract and secondary glauco
ma was statistically significant.
Conclusion: A significant relationship between the amount of after-cataract
and the development of secondary glaucoma was found in aphakic infant rabb
it eyes. (C) 2000 ASCRS and ESCRS.