UVEAL LYMPHOID NEOPLASIA - A CLINICAL-PATHOLOGICAL CORRELATION AND REVIEW OF THE EARLY FORM

We report three cases of uveal lymphoid neoplasia that were diagnosed early in their course. One case exhibited a posterior form, presenting with progressive hyperopia from a serous macular detachment and choro idal involvement along with retrobulbar involvement. This patient was treated with proton beam irradiation. Two cases displayed an anterior form, with fixed fleshy epibulbar masses resembling salmon patches, an d choroidal involvement. The histologic findings from biopsy of these anterior masses are presented. One of these patients was treated with complete excision of the mass and double freeze-thaw cryotherapy of th e scleral bed, and the other patient was treated with conventional pho ton beam irradiation. The clinical features of uveal lymphoid neoplasi a in its early form are discussed. Evaluation and treatment strategies for these early forms of uveal lymphoid neoplasia are reviewed. (C) 1 997 by Elsevier Science Inc. All rights reserved.