This paper presents an efficient approach far obtaining wasteload allocatio
n solutions that provide the optimal trade-off between treatment cost and r
eliability. This approach links a genetic algorithm (GA) with the first-ord
er reliability method (FORM) for estimating the probability of system failu
re under a given wasteload allocation. The GA-FORM optimization approach is
demonstrated for the case study of managing water quality in the Willamett
e River in Oregon. The objective function minimizes the sum of the treatmen
t cost and the penalty associated with breaching a reliability target for m
eeting a water quality standard. The random variables used to generate the
reliability estimates include streamflow, temperature, and reaeration coeff
icient values. The results obtained indicate that the GA-FORM approach is n
early as accurate as the approach that links the GA with Monte Carlo simula
tion and is far more efficient. The trade-off between total treatment cost
and reliability becomes more pronounced at higher water quality standards a
nd is most sensitive to the uncertainty in the reaeration coefficient. The
sensitivity to the reaeration coefficient also increases at increased relia
bility levels.